The Use of ATP-MgC1(2) in the Treatment of Injury and Shock.
Abstract
Studies have shown that reticuloendothelial (RE) function was significantly depressed following hepatic ischemia and that infusion of ATP-MgCl2 following ischemia corrected the impairment in RF function. The potential for administration of ATP-MgCl2 as passive therapy at a time of marked RE depression following ischemia suggests a new therapeutic modality in the treatment of hepatic ischemia. Our results have also shown that infusion of adenine nucleotides-MgCl2 following severe renal insult significantly improves renal function and suggests that these agents may effectively accelerate the recovery from acute renal failure. Moreover, our results indicate that the accelerated recovery of renal function by ATP-MgCl2 was concentration dependent and that optimal effects were observed with 50 moles of ATP-50 moles of MgCl2. These observations have important implications for future use in organ preservation and management of post-ischemic renal failure. Studies with sepsis have shown that hepatic function was impaired during sepsis and that impaired liver function during sepsis may not only have significance in terms of host defense against bacteremia but may also be associated with pulmonary changes which jeopardize the animals as well. Originator supplied keywords include: Sepsis, Reticuloendothelial function, Splenectomy, Hepatic, Ischemia, ATP-MgCl2, Positive end-expiratory pressure, Pneumonia, Prostaglandins, Alveolar macrophage, Hepatic function, Red blood cells, and Hypertonic solutions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1979
- Accession Number
- ADA151839
Entities
People
- A. E. Baue
- I. H. Chaudry
Organizations
- Yale University