Effects of Organophosphates on Transmitter Controlled Ionic Channels.

Abstract

We have examined the postsynaptic blocking effects of thiamine (Vitamin B1), guanethidine, phenethylguanidine, hycanthone and memantin on the neuromuscular junction, using voltage clamp and noise analysis. Experiment I pertains to Postsynaptic effects of some drugs on the frog neuromuscular junction. Experiment II pertains to the mode of action of organophosphates at the frog neuromuscular junction. The goal of the research was to investigate the kinetics of organophosphate block of the acetylcholine receptor-channel complex (AChR). The goal of the present research was to investigate further organophosphate-AChR binding kinetics using two organophosphate pesticides, 2,2 dichlorovinyl dimethylphosphate (DDVP) and 3-hydroxy-n,n-dimethyl-cis-crotonamide dimethylphosphate (dicrotophos), which have been reported to block the depolarization of frog muscle by carbamylcholine (Dekin et al., 1978) and ACh binding to isolated AChR from eel electroplax (Eldefrawi et al., 1982). Originator supplied keywords include: Drugs, Neuromuscular junctions, Acetylcholine, Thiamine, Guanethidine, Phenethylguanidine, Hycanthone, Memantin.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1985
Accession Number
ADA153046

Entities

People

  • Chelsea E. R. Edwards

Organizations

  • State University of New York at Albany

Tags

Communities of Interest

  • Engineered Resilient Systems

DTIC Thesaurus Topics

  • Acetylcholinesterases
  • Chemical Synthesis
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemistry
  • Electrodes
  • Enzyme Inhibitors
  • Frequency
  • Kinetics
  • Membrane Potentials
  • Muscle Fibers
  • Muscles
  • Neuromuscular Transmission
  • Pesticides
  • Power Spectra
  • Resistance
  • Skeletal Muscle

Readers

  • Neuroscience
  • Neurotoxicology