Microwave-Induced Cataracts of the Eye Lens: Strategies for Modelling and Prevention in Vitro and In Vivo.
Abstract
Rat ocular lenses were studied after fixation and critical point drying of the tissue by scanning electron microscopy (SEM) following exposures to elevated temperatures and/or microwave irradiation in a thermostatically controlled chamber. In this way, the temperature of the lens bathing medium was set independently of the temperature increase normally associated with application of microwave power. Irradiations were done at three final temperatures and five specific absorption rates (SAR) for two durations. These were accomplished at 915 MHz in WR975 waveguide with either pulsed (Pu) or continuous wave (CW) radiation of equal average power. The parameters of the (Pu) radiation were selected to maximize the production of thermoacoustic expansion. In addition to the types of damage noted on previous progress reports: (1) immediately after pulsed microwave irradiation, holes in cell membranes (2) after incubation for 48 hr, globular degeneration including very large globules at high SAR's and 37 C, this work has investigated possible reciprocity between time and SAR; and threshold dosage (for 6 min exposures) for damage to lenses in vitro by pulsed microwaves at low average power ratings but high peak power in the pulses. Originator supplied keywords include: Tissue culture, Globular degeneration, Cataract vitamin E prevention.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1982
- Accession Number
- ADA153855
Entities
People
- J. R. Trevithick
Organizations
- Western University