Study of African Trypanosomiasis.
Abstract
The pathogenesis of Trypanosoma brucei rhodesiense was studied in 42 cattle experimentally infected with different isolates from Kenya, Ethiopia and Tanzania. Nineteen of the cattle died or were terminated in extremis 3-60 months post inoculation. Nine of 11 isolates tested produced central nervous system (CNS) disorder in the cattle. The CNS disorders developed early (3 months) in some animals and later (60 months) in others. Parasites were difficult to find on wet blood smears or by subinoculations of blood after the fourther month of infection. Parasites persisted in lymph nodes, however. It appears that the bovine is a suitable model for T.b. rhodesiense infection with syndromes similar to those in human infections. Berenil (R) treatment of hosts and subsequent transmission of T. congolense and T. vivax by tsetse flies were investigated. The complement fixation (CF) test and the micro-ELISA were compared in the diagnosis of visceral leishmaniasis, Originator-supplied keywords include: Glossina morsitans, kala-azar, Leishmania donovani, and Complement fixation test.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1980
- Accession Number
- ADA154092
Entities
People
- B. T. Wellde
- I. Muriithi
- L. W. Roberts
- M. J. Reardon
- W. T. Hockmeyer
Organizations
- United States Army Medical Research Unit-Kenya