Study of African Trypanosomiasis.
Abstract
Studies of natural and acquired resistance of bovines to Trypanosoma congolense showed that age resistance was substantial. Most (91%) of bovines under 1 year old survived infection without treatment, while only 11% of the; animals between 1 and 2 years old and none of those over 2 years old survived without treatment. Specific material antibody was not involved, since all calves were from non-infected dams and had been weaned at least 1 month prior to infection. Animals that self-cured remained resistant for extended periods of time to homologous strain challenge either by syringe inoculation or infected Glossina morsitans feedings. Infected animals receiving Berenil treatment also showed resistance to subsequent syringe or tsetse challenge with the same strain. No cross strain immunity was apparent either against blood or tsetse fly induced infections in any of the animals tested. Survival times of 51 Cr-labeled thrombocytes were compared in T. congolense infected and normal steers. The culture of Leishmania donovani in Schneider's insect medium was evaluated as a means of diagnosis and management of patients with visceral leishmaniasis. The culture technique appears more sensitive than stained smear examination and thus provides a better method of assessing the effectiveness of drug therapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1979
- Accession Number
- ADA154189
Entities
People
- B. T. Wellde
- I. Muriithi
- L. W. Roberts
- R. M. Kovatch
- W. T. Hockmeyer
Organizations
- United States Army Medical Research Unit-Kenya