Research and Development of Wound Dressing in Maxillofacial Trauma.
Abstract
Three basic formulations, non-woven fabrics, powders, and microcapsules, of local anesthetic agents, antiseptics, and antibiotics were prepared with poly-L(-)lactide as the polymer. These formulations were characterized by scanning electron microscopy, EDAX (energy dispersive analysis of X-rays), in vitro drug release rate, in vivo efficacy, and stability during storage. The rate of drug release from the matrix was altered by changing drug-polymer ratios, by adding detergent (S.D.S.), by size selection, and by combining fabrics with powders and microcapsules. Sustained release formulations of benzocaine, bupivacaine-HCl, etidocaine-HCl, and lidocaine base, hydrochloride, and sulfate were studied. Sustained release formulations of four antiseptics, benzalkonium chloride, povidone iodine (PVP-I2), nitrofurazone, and chlorhexidine diphosphanilate were studied. Sustained release formulations of amplicillin (trihydrate and anhydrous) released drug over a prolonged period. Clindamycin formulations released drug rapidly in all test systems. Originator supplied keywords include: Wound healing, Antiinfectives and antibacterials, and Hemostatics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 16, 1984
- Accession Number
- ADA154270
Entities
People
- D. E. Creeden
- D. L. Williams
- J. H. Kerrigan
- M. H. Gay
- W. A. Nucefora