Molecular Toxicology of Chromatin: The Role of Poly(ADP-Ribose) in Gene Control.

Abstract

This report pertains to the following research projects: Chemical and macromolecular structure of poly(ADP-ribose)1. HPLC-isolation of poly(ADP-ribose.). 2. Fractionation, size analysis branching of poly (ADP-ribose) by HPLC and chemical analysis of subunits. 3. Mathematical model of polymerization of ADP-ribose. II. Biosystems. III. Molecular studies on purified poly(ADP-ribosylation in cellular and subcellular systems. III. Molecular studies on purified poly(ADP-ribose) polymerase system. 1. DNA-association of benzamide. 2. The role of lysine residues in the catalysis and DNA binding of poly(ADP-ribose)polymerase. IV. Cell transformation and poly ADP-ribosylation. 1. Inhibition of carcinogen initiated transformation. 2. Ultraviolet light induced transformation and its inhibition.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1985
Accession Number
ADA154415

Entities

People

  • E. Kun

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Albumins
  • Alcohols
  • Amides
  • Biology
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Chemical Analysis
  • Chemistry
  • Fibroblasts
  • Liquid Chromatography
  • Molecules
  • Pharmacology
  • Polymers
  • Proteins
  • Toxicology

Fields of Study

  • Biology
  • Chemistry

Readers

  • Geochemistry
  • Molecular Genetics
  • Molecular and Cellular Biochemistry