Phosphoprotein Regulation of Synaptic Reactivity: Enhancement and Control of a Molecular Gating Mechanism.

Abstract

Protein Fl, a brain specific synaptically located protein, is phosphorylated in direct relation to the enhancement of synaptic communication. Studies demonstrated that the kinase involved in phosphorylation of protein Fl is protein kinase C. Results suggest that the mode of activation of the kinase C by synaptic enhancement may involve translocation of the enzyme from the cytosol to the cell membrane.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1985
Accession Number
ADA154511

Entities

People

  • A. Routtenberg

Organizations

  • Northwestern University

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Biological Sciences
  • Brain
  • Cells
  • Cellular Structures
  • Cerebral Cortex
  • Chemistry
  • Classification
  • Enzymes
  • Gel Electrophoresis
  • Kinases
  • Medical Personnel
  • Neurons
  • Neurosciences
  • New York
  • Phosphorylation
  • Proteins
  • Two Dimensional

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Neuroscience