Studies of Circulatory and Metabolic Changes during Ketamine Narcosis,
Abstract
Among commonly used anesthetics, ketamine obviously occupies an unusual position. While most anesthetics exert a retarding effect on circulation and metabolism, ketamine clearly has the opposite effect. Figure 1 shows the synopsis of the most important circulatory characteristics after a representative individual test. The injection of ketamine in the animal test causes an increases in heart frequency (HF), HZV (lower curve), coronary blood supply (Vcor) and the myocardial 02 consumption, together with a reduction in coronary venous saturation (upper falling curve). The pressures and the rate of decrease are higher. Eight mongrel dogs weighing between 19 and 27 kg were pre-medicated with 1 mg of scopalamine and 30 minutes later received intravenously on average 20 mg/kg body weight of ketamine which produced in them a condition similar to narcosis. The behavior of PCO2, pH bases excess and the average arterial pressure, heart beat and the central venous pressure during ketamine is discussed. The change in heart beat and the plasma concentration of noradrenaline, adrenaline, glucose and free fatty acids during ketamine narcosis is reported. Oxygen consumption during ketamine narcosis after administration of a muscle relaxant and a morphine derivative is also reportered.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 13, 1985
- Accession Number
- ADA154512
Entities
People
- D. Kettler
- D. Knoll
- I. Hensel
- Jason Martel
- U. Braun
Organizations
- National Air and Space Intelligence Center