Interaction of Opiate and Phencyclidine Derivatives with the Acetylcholine Receptor.

Abstract

The purpose of this work was to define the structural and biochemical environment of the AChR/I and the relationship of drug structure to the resultant pharmacological response. A number of drugs were tested using both biochemical and electrophysiological tests. For the most part, compounds consisted of benzomorphan and phencyclidine analogs, with the benzomorphans being the more thoroughly tested. Several important portions of the benzomorphan structure were identified, and the results of varying substitutents suggested that hydrophobicity parameters were the most important determinants of binding affinity. Originator supplied keywords: Acetylcholine receptor; Cholinergic receptor; Opiates, Phencyclidine, Neuromuscular junction.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1985
Accession Number
ADA155119

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  • R. E. Oswald

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