Carcinogenesis of Nitrated Toluenes and Benzenes Skin and Lung Tumor Assays in Mice
Abstract
A series of nitrated toluenes and benzene were tested for their capability to act as initiators, promoters or complete carcinogens in mouse skin. 2,6-dinitrotoluenes and 2-nitrotoluene were found to have weak skin tumor initiating activity. 2,4-dinitrotoluene, 2,6-dinitrotoluenes and 1,3,5- trinitrobenzene produced historical changes in skin which usually are produced by promoting agents; this finding suggests that the three compounds could have skin tumor promoting activity. However, a firm conclusion can only be reached following appropriate in vivo tests. In the lung tumor assay, none of the chemicals tested gave an unequivocal positive response. A borderline positive result for unpurified 2,6-dinitrotoluene could not be repeated when the purified compound was reassayed in the same assay.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1985
- Accession Number
- ADA155723
Entities
People
- H. P. Witschi
- L. H. Smith
- L. L. Triplett
- T. J. Slaga
Organizations
- Oak Ridge National Laboratory