Studies on the Inhalation Toxicity of Dyes Present in Colored Smoke Munitions. Phase III, Studies: Four-Week Inhalation Exposures of Rats to Dye Aerosols.
Abstract
The USAMBRDL has an interest in the potential inhalation toxicity of yellow dye (SY) and a yellow/green dye mixture (SY/SG) used in colored smoke munitions. Rats were exposed by inhalation to aerosols of SY or SY/SG generated in a respirable particle size range for 6 hr/day, 5 days/week for 4 weeks. Nominal exposure concentrations selected for both dye exposures were 0, 10, 50, and 250 mg/cum. Animals exposed to the highest concentration of SY (230mg/cum) showed only a slight decrease in weight gain (8 percent) and mild respiratory function changes, with no observable histopathological lesions. Exposure to the lower concentrations of SY dye elicited no observed response. Animals exposed to the highest level of SY/SG dye (210 mg/cum) displayed signs of pulmonary inflammation with histopathological evidence of mild Type II pulmonary epithelial cell hyperplasia and proliferation of foamy alveolar macrophages. Some of the animals exposed to the medium concentration of SY/SG dye mixture (49 mg/cum) showed similar signs. Thus, the lowest toxic exposure concentration of SY dye is > or = 230 mg/cum and that of SY/SG dye is > or = 50 mg/cum under the exposure regime used. Originator supplied keywords include: Solvent Yellow; Solvent Green; 2-(2'-quinolyl)-1,3-indandione, 1,4-di-p-toluidinoanthraquinone.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 10, 1984
- Accession Number
- ADA156698
Entities
People
- D. E. Bice
- F. F. Hahn
- J. S. Dutcher
- T. C. Marshall
- Y. S. Cheng
Organizations
- Lovelace Foundation