Study of Toxic and Antigenic Structures of Botulinum Neurotoxins
Abstract
Amino acid composition of botulinum neurotoxin (NT) types A and B were determined. The heavy and light chains of types A and B NT were separated, purified and analyzed for amino acid compositions and partial N-terminal sequence. The single chain type B and E NT were also partially sequenced. Role of tyr, his residues and carboxyl groups in toxicity and antigenicity were determined. Originator supplied keywords include: Botulinum neurotoxin; heavy chain; light chain; amino acid composition; amino acid sequence; subunit chain isolation; structure-function relationship; selective modification; immunogen; antiserum.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1984
- Accession Number
- ADA156727
Entities
People
- B. R. Dasgupta
Organizations
- University of Wisconsin–Madison