Bioassay of Military Relevant Compounds for Carcinogenic Activity by the Strain A Mouse Lung Tumor Bioassay
Abstract
Two dye compounds, C.I. Solvent Yellow 33 and a mixture of C.I. Solvent Green 3-C.I. Solvent Yellow 33, utilized in colored smoke grenades, were tested for carcinogenic potential in the strain A mouse lung tumor bioassay. The maximum tolerated dose for each dye was determined to be 25 mg/kg. At total doses of 600, 300 and 120 mg/kg, C.I. Solvent Yellow 33 and a mixture of C.I. Solvent Green 3-C.I. Solvent Yellow 33 did not produce an increase in the lung tumor response (i.e., the percentage of mice with lung tumors or the mean number of lung tumors per mouse) when compared to vehicle (tricaprylin) controls. Therefore, at the dose levels administered both dyes were non-carcinogenic in the strain A mouse lung tumor bioassay under the conditions of the test. At necropsy, mice tested with either compound had significant quantities of accumulated dye in their tissues. This observation suggests that the dyes were either not metabolized or only partially metabolized by the animals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1985
- Accession Number
- ADA156772
Entities
People
- G. D. Stoner
Organizations
- University of Toledo Medical Center