Pharmacology of Periodontal Disease.
Abstract
The specific aim of this contract is to 'identify antibacterial and anti-inflammatory agents, used individually or in combination, which are appropriate for preventing the exacerbation of acute periodontal disease under field conditions,' and our first year milestone involves the establishment of anatomical and biochemical approaches for the quantitative evaluation of these drugs. This milestone has essentially been completed, though our methodological approach has been changed. We originally proposed to use the rice rat model as a system to evaluate the effects of the various drugs on periodontal disease. However, after several discussions with the research group at the Naval Dental Research Institute (Great Lakes Naval Base) and our own re-evaluation of the current literature and the specific aims of this study, we decided to begin our studies on isolated human polymorphonuclear leukocytes (PMN).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 24, 1985
- Accession Number
- ADA157116
Entities
People
- S. F. Hoff