Chemoreceptor Function and Regulation in Cultured Vertebrate Neurons.
Abstract
Cultured vertebrate neurons (aviam ciliary ganglion) were used as a model system to study the interactive regulation of neuronal sensitivity to neurotransmitters (acetylcholine, GABA, glycine, enkephalin). Sensitivity was found to be influenced by direct contact with specific target-cell membranes, the interaction depending upon a molecule or molecular complex in the target cell membrane, for the excitatory input receptor but not the other receptor types. This novel form of regulatory interaction may have broad significance to neuronal dynamics. The results to date pave the way to an understanding of receptor regulation at the molecular level.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1985
- Accession Number
- ADA157275
Entities
People
- J. B. Tuttle
Organizations
- University of Connecticut