A Program for Clinical Care in Physical Trauma.

Abstract

A septic sheep model has been developed which is similar to extensive cellulitis secondary to penetrating injury of the leg. This model increases the release of skeletal muscle amino acids, fails to develop ketosis during starvation and injury/infection, and appears suitable to evaluate therapies that would reverse the catabolic effects of injury. Protein turnover, determined in trauma-septic patients using stable isotopes, is increased. The increase in breakdown exceeds synthesis, and these alterations in amino acid metabolism account for the negative nitrogen balance following injury. Keywords: exogenous substrate; catabolic response.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1981
Accession Number
ADA157300

Entities

People

  • D. W. Wilmore

Organizations

  • Harvard University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Anesthesia
  • Animals
  • Biomedical Research
  • Blood
  • Body Weight
  • Cardiovascular Physiological Phenomena
  • Catabolism
  • Catheters
  • Infection
  • Laboratory Animals
  • Plastic Explosives
  • Tissues
  • Veins
  • Vena Cava
  • Wound Infections
  • Wounds And Injuries

Readers

  • Cardiovascular Physiology
  • Exercise and Sports Science.
  • Trauma Surgery or Emergency Medicine.