Molecular Mechanisms Involved in Tissue Swelling Due to Injury and Due to Exposure to Low Temperature and Massive Water and Electrolyte Loss in Diarrheal Disorders.
Abstract
The major conclusion to be drawn from the ONR-supported research is that the basic tenets of the membrane-pump theory, which has dominated biological thinking for nearly a century and is still being taught in most textbooks at all levels of education, is untenable and incorrect. The cells do not have enough energy to operate all the pumps. The ability of living cells to maintain constant levels of solutes like Na+, sugars, free amino acids, reflect primarily two basic mechanisms: selective adsorption on protein sites (e.g., most cell K+) and partial exclusion from cell water at levels roughly inversely proportional to the size and complexity of the solutes and hydrated ions involved. Osmotic activity of the cell is not due to intracellular ions (which are largely adsorbed) but is due to the multilayer polarization of the cell water. Cellular resting potential is not a membrane potential with or without an electrogenic pump component; it is a surface adsorption potential. ATP adsorbed on cardinal sites on cellular proteins maintain the cellular assembly of proteins-water-ions in a high energy state - the living state. Electronic inductive effect underlies the allosteric action of ATP as well as those of Ca++, hormones, and drugs that act on cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 28, 1985
- Accession Number
- ADA157332
Entities
People
- G. N. Ling