Stability of T-2 Mycotoxin in Aqueous Media

Abstract

Radiolabeled (3H)T-2 mycotoxin was dissolved in various aqueous media and stored for up to 3 weeks at 4,22, and 37 C. At periods ranging from 1 to 21 days, aliquots were assayed by thin layer chromatography. Breakdown products were identified based on their co-migration with known standards. Results indicated that T-2 toxin was most stable in tissue culture medium with or without serum, compared to HBSS, at all temperatures. The metabolites HT-2, T-2 triol, and T-2 tetraol were detected in decreasing concentrations, as early as 1 day (HBSS, 37 C) and as late as 3 weeks (HBSS, 4 C). Stability of the toxin in aqueous media decreased with increasing temperature.

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Document Details

Document Type
Technical Report
Publication Date
May 20, 1985
Accession Number
ADA157567

Entities

People

  • Lynn R. Trusal

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Alcohols
  • Amino Acids
  • Aqueous Solutions
  • Biomedical Research
  • Chromatography
  • Culture Media
  • Department Of Defense
  • Fungi
  • Infectious Diseases
  • Low Temperature
  • Methanols
  • Mycotoxins
  • New England
  • Security
  • Thin Layer Chromatography
  • Tissue Culture

Readers

  • Analytical Chemistry
  • Mathematics or Statistics
  • Mycotoxin ecology in Amazonian ecosystems.