Health Hazard Evaluation of Liquid Monopropellants. Phase 4. Subchronic Inhalation of Hydroxylammonium Nitrate, January 1985.
Abstract
This study was conducted to determine the effects of repeated airborne exposures to animals of hydroxylammonium nitrate (HAN), a major component of liquid gun propellants. This evaluation will assist in advising on the potential health risks associated with handling these materials. Rats and dogs were exposed to aerosolized HAN for 90 days at concentrations of 300, 100, and 33 mg/cu m. Dose-related effects occurred in both species and were characterized in rats by weight loss and spleen and liver enlargement. In dogs, respiratory irritation and blood dyscrasia were the major toxic effects. Minimal effects were observed at the low dose, 33 mg/cu m. Personnel should be protected against all routes of HAN exposure since the systemic effects are additive. An airborne concentration of HAN at 3 mg/cu m may be considered as a basis for the development of a maximum allowable workplace atmosphere. Accidental exposures in man should be closely monitored for cyanosis, anemia and respiratory distress. Treatment for methemoglobinemia may be indicated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 19, 1985
- Accession Number
- ADA157623
Entities
Organizations
- United States Army Medical Command