Prospective Randomized Trial of Naloxone versus Dopamine as Adjunctive Therapy for Bacteremic Shock.
Abstract
This study assesses the efficacy of naloxone in the therapy of septic shock. The operating protocol was revised during this first year of the study. The original protocol (protocol 1), patients (7) were randomized to receive either dopamine or naloxone in increasing bolus doses up to 1 mg/kg followed by continuous naloxone infusion. Of 4 patients given naloxone, 2 responded, with increases in mean arterial pressure (MAP) of 30% within 10 minutes. Pressures fell however after 70 minutes and 6 hours despite continued drug infusion. Three patients given dopamine responded, although this occurred more slowly (1-2 hours). Survival was unrelated to therapy or hemodynamic response. Infections were present in 4 of 7 patients. In the revised protocol (protocol II), patients received naloxone or a placebo, (double-blinded and radomized), designated A or B (code not yet broken), given as a single IV bolus of 1 mg/kg followed by a continuous IV infusion of 70% of the bolus dose. If a hemodynamic response does not occur within 10 minutes, the patient then receives conventional therapy. Based on results from the original protocol, naloxone appears effective in some patients, although on occasion only transiently.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 04, 1984
- Accession Number
- ADA157721
Entities
People
- G. P. Aurigemma
- H. F. Chambers
- H. Fullman
- M. A. Sande
- N. Benowitz
Organizations
- University of California, San Francisco