Testing Experimental Compounds against American Cutaneous and Mucocutaneous Leishmaniasis
Abstract
Over a two year period under this contract, eight WRAIR compounds have been tested against two subspecies of Leishmania m. mexicana, Leishmania donovani, or Leishmania braziliensis. In the visceral model, 6 of eight WRAIR experimental aminoquinolines were as active as the standard antimonial Pentostam in decreasing spleen and liver parasite burdens, as shown by Pentostam Indices of 1.4 to 11.8. However, spleens from these mice were all culture positive so that no cures were achieved with them. Cutaneous and mucocutaneous infections were only slightly altered by experimental drug treatment. None of the Therapeutic Indices of these drugs was competitive with Pentostam (TI = 1.20 to 2.00 v/s 160). Three types of combination chemotherapy were tested against visceral, cutaneous, and/or mucocutaneous infections in BALB/c mice. These included systemic and topical application of Pentostam against L. braziliensis, Pentostam and bacille Calmette Guerin (BCG) against L. mexicana infections, and alpha D,L-difluoromethylornithine (DFMO) in combination with Bleomycin against L. donovani
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1982
- Accession Number
- ADA157956
Entities
People
- Jan S. Keithly
Organizations
- Weill Cornell Medicine