Partial Purification and Properties of Bovine and Ovine Spinal Cord Acetylcholinesterases,

Abstract

Methods were developed for the solubilization of spinal cord acetylcholinesterases from cows and sheep. Several characteristics of this preparation are reported, including the results of attempts at purification. A method for bovine enzyme achieved an 80-fold purification from the spinal cord homogenate. Comparison studies with similiar enzymes from other species and tissues may help elucidate the mechanism of organophosphate poisoning.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1985
Accession Number
ADA159356

Entities

People

  • A. R. Bhatti
  • R. G. Smyth

Organizations

  • Defence Research and Development Canada

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acetylcholinesterases
  • Central Nervous System
  • Chemical Synthesis
  • Chemistry
  • Chromatography
  • Electrophoresis
  • Extraction
  • Nerve Agents
  • Nervous System
  • Organophosphates
  • Photography
  • Poisoning
  • Recovery
  • Spinal Cord
  • Standards
  • Visualizations

Fields of Study

  • Agricultural and Food sciences

Readers

  • Molecular and Cellular Biochemistry
  • Neurotoxicology
  • Neurotrauma and Rehabilitation Medicine.