Metabolism of Benzo(A)Pyrene and Diethylnitrosamine by Lung Cells of Rats, Mice, and Hamsters.
Abstract
The work described in this report has addressed the problem of comparative metabolism of xenobiotics among the common laboratory species of rat, mouse, and hamster. The problem has been approached in two ways. The first method has been able to conduct comparative studies with lung cells isolated from the three common laboratory species with respect to their metabolic activity toward an ubiquitous environmental carcinogen, benzo(a)pyrene (BaP). The results have indicated that the various lung cell types have widely different levels of enzymatic activity, and that this activity can be modified by prior treatment of the experimental animals. The second approach has been to examine xenobiotic metabolism within a single species and to conduct a detailed study of the metabolism and binding of an organotropic carcinogen, diethylnitrosamine (DEN), in target and nontarget cells and tissues of the hamster.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1985
- Accession Number
- ADA159383
Entities
People
- A. T. Fong
- R. E. Rasmussen
Organizations
- University of California, Irvine