Health Effects Research on Munition Contaminated Dimethyl Sulfoxide Recrystallization Process Solvent. Phase I Studies.
Abstract
Sample material was taken from a dimethylsulfoxide (DMSO) recrystallization process pilot plant and examined chemically and toxicologically. The work performed to meet Phase I of the research program has been completed. This includes a problem definition study, the chemical and physical characterization of process stream samples and toxicological studies (oral LD50 in rats and mice, primary ocular and dermal irritation in rabbits, acute dermal toxicity in rabbits, dermal sensitization in guinea pigs, Ames assay, and mouse lymphoma mammalian cell assay) on the recycle solvent and evaporator sludge. Since both the latter were identified as having direct-acting mutagens, research objectives for subsequent phases were changed in order to identify the mutagenic agent in the mixtures. Originator supplied keywords include: Acetone; Benzothiazole; Carcinogenicity; Cyclohexanone; Hexahydro-1- acetyl-3,5-dinitro-1,3,5-triazine (TAX); Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX); Octahydro-1-acetyl-3,5,7-trinitro-1,3,5,7-tetrazocine (SEX); Octahydro-1, 3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1985
- Accession Number
- ADA159418
Entities
People
- D. L. Parmer
- J. C. Dacre
- J. W. Carroll
Organizations
- United States Army Medical Research and Development Command