Applied Laboratory and Clinical Studies on Biodegradable Ceramic.
Abstract
This report summarizes the 1982 - 1983 USAIDR sponsored studies on particulate and rod form tricalcium phosphate ceramic for bone replacement. The middle portion of twenty New Zealand White Rabbit tibia were implanted with the new -40+100 mesh particulate form TCP in quantities of 0.4 and 0.8 grams or as mixtures of 0.2 and 0.2 or 0.4 and 0.4 grams of TCP and autogenous bone. The rabbits were followed to 36 weeks post surgery. Eight dogs with middle radii rod form TCP implants were reviewed and implants from 24, 48 and 63 months post implantation evaluated. From these studies, the following conclusions were drawn. The mixtures of TCP and autogenous bone showed a slightly higher probability for clinical union and long term follow up (7/10) compared to the TCP alone (5/10). Histological studies showed this particulate form of TCP to be retained at 36 weeks and to be biocompatibe with bone. The structure of the NEW particulate TCP shows a less porous substance when compared with the former TCP particulate. The dog radii implants of rod form TCP removed at 24, 48 and 63 months showed retained TCP. Federal Drug Administration approval for the human investigations of particulate form TCP and autogenous bone was granted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 1983
- Accession Number
- ADA159436
Entities
People
- J. E. Lemons
Organizations
- University of Alabama