Applied Laboratory and Clinical Studies on Biodegradable Ceramic.

Abstract

Investigations on granular form tricalcium phosphate (TCP) and calcium hydroxylapatite (CaHA) ceramics and rod form tricalcium phosphate ceramic have continued in laboratory animal models. Segmental lesions at the middle region of rabbit tibiae that were filled with mixtures of TCP, CaHA and autogeneous bone showed healing and good biocompatibility. Eleven of twelve rabbits demonstrated biomechanical stability of the tibiae at euthanization. Rod form TCP segmental replacements at the middle region of dog radii showed residual TCP (radiographically) at four years post surgery. The animals continue without functional limitations. Human clinical trials of granular form TCP and autogeneous bone have not been initiated at this time. Approval for this study is anticipated during 1982.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1982
Accession Number
ADA159628

Entities

People

  • J. E. Lemons

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Animals
  • Biocompatible Materials
  • Biomedical Research
  • Bone Fractures
  • Bones
  • Ceramic Materials
  • Classification
  • Clinical Trials
  • Contracts
  • Drug Overdose
  • Infection
  • Laboratory Animals
  • Materials
  • Security
  • Surgery
  • Test And Evaluation
  • Wound Infections

Readers

  • Trauma Surgery or Emergency Medicine.