Determination of the Chronic Mammalian Toxicological Effects of RDX: (Twenty-Four Month Chronic Toxicity/Carcinogenicity Study of Hexahydro-1,3,5- Trinitro-1,3,5-Triazine (RDX) in the Fischer 344 Rat). Volume 1.
Abstract
This study was conducted to evaluate the toxicity of the munition compound hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX; CAS Reg. No. 121-82-4) in Fischer 344 rats when administrated in their diet for up to 24 months. Groups of 75 rats per sex received RDX at doses of 0, 0.3, 1, 5, 8, or 40 mg/kg/day. Ten rats/ sex/dose were killed following 6 and 12 months on test with surviving animals killed after 24 months of treatment. Toxicologic endpoints included clinical signs, body weights, food consumption, hematology, clinical chemistry, opthalmology, organ weights, and gross and tissue morphology. The major toxic effects observed during the administration of RDX to F344 rats up to 24 months included anemia with secondary splenic lesion, hepatoxicity, possible CNS involvement, cataracts and urogenital lesions. Based on the observance of increased levels of a hemosiderin-like pigment deposited in the spleen (a secondary response to a hemolytic-type anemia) and suppurative inflammation of the prostate for rats administered 1.5 mg/kg/day or greater, the no-effect level under conditions of the present study is 0.3 mg/kg/day.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1983
- Accession Number
- ADA160774
Entities
People
- Barry S. Levine
- Donovan E. Gordon
- E. M. Furedi
- Paul M. Lish
- Vladislava S. Rac
Organizations
- IIT Research Institute