A Biodegradable Implant for Restoring Bone Discontinuity Defects in Dogs,

Abstract

A copolymer (polylactic acid: polyglycolic acid) was combined with a proteolipid (PL) and the resulting implant complex was rigidly fixed into discontinuities in the mandibles of 25 adult, foxhound dogs. Identically prepared control discontinuities in contralateral sites in the same animals did not receive the complex and were rigidly fixed. At 4, 8, 12, 24, 40 weeks the dogs were sacrificed and implant and controls were prepared for histomorphometry. Histomorphometric evaluation revealed there was a linear increase of bony reparative elements in the implants over 40 weeks that exceeded those of the nontreated control sites. The copolymer-PL implant, therefore, may provide an alternative to autogeneic and allogenic bone substances. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 1985
Accession Number
ADA161312

Entities

People

  • Jeffrey O. Hollinger
  • John P. Schmitz

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Ablation
  • Alcohols
  • Analysis Of Variance
  • Data Analysis
  • Growth Factors
  • Laboratory Animals
  • Materials
  • Maxilla
  • Membrane Lipids
  • Osteogenesis
  • Polymers
  • Prostheses And Implants
  • Prosthetics
  • Standards
  • Surgery
  • Teeth
  • Test And Evaluation

Readers

  • Structural Dynamics.
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Microelectronics