Systemic Antibody Response of Clinically Characterized Patients with Antigens of Eubacterium brachy Initially and Following Periodontal Therapy,

Abstract

Eubacterium brachy, a Gram (+) positive anaerobic rod, has been implicated by cultural studies to be associated with the microflora of periodontal diseases. Serum samples from 184 clinically characterized patients were evaluated in a standardized enzyme-linked immunosorbent assay (ELISA) for reactivity to E. brachy antigens. Sera from clinically healthy subjects ( HS) served as controls. Sera from rapidly progressive periodontitis (RP) patients demonstrated significantly greater reactivity by ELISA than did HS when reactivity with E. brachy antigens was determined (P< .001). Juvenile periodontitis (AP) patients did not differ in reactivity by ELISA from HS (P < .05). Three to four years following successful periodontal therapy, reactivity was not significantly altered in any patient group ( P > .05). The possible significance of these findings and the importance of an extracellular antigen of E. brachy in the immunopathology of periodontal diseases are discussed. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Nov 21, 1985
Accession Number
ADA162104

Entities

People

  • Jack W. Vincent
  • Jon B. Suzuki
  • William A. Falkler Jr.

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Albumins
  • Antibodies
  • Bacteriology
  • Classification
  • Coatings
  • Dilution
  • Enzymes
  • Health Services
  • Materials
  • Microbiology
  • Microorganisms
  • Mouth Diseases
  • Osteoporosis
  • Security
  • Statistical Analysis
  • Teeth
  • Therapy

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Trauma Surgery or Emergency Medicine.