Chemotherapy of Rodent Malaria.
Abstract
The report describes antimalarial studies performed on 63 compounds, mainly supplied by WRAIR, to determine blood schizontocidal, causal prophylactic and gametocytocidal activity. Data from tests on a range of putative primaquine metabolites are included. The development is described of two lines of Plasmodium berghei resistant to the Mannich base, WR228258. Mode of action studies on this compound, on a second Mannich base - WR194965 and on an 8-aminoquinoline, WR225448, are reported. Keywords: Plasmodium yoelii nigeriensis; Resistance (biology); Floxacrine; Quinine; Phenanthrene alcohols; Mefloquine; Saframycin A; Clopidol. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1983
- Accession Number
- ADA162414
Entities
People
- Wallace Peters
Organizations
- London School of Hygiene & Tropical Medicine