Nonspecific Resistance Induced by an Immunopharmacologic Agent Derived from Bordetella pertussis

Abstract

Administration of Bordetella pertussis vaccine intraperitoneally induces resistance to mouse adenovirus infection. Subcellular fractions of B. pertussis are capable of inducing resistance also. Boivin antigen, a trichloroacetic acid-soluble extract of whole cells, is capable of inducing resistance in the dose range of 0.2-2.0 ug when adsorbed to alum. Biochemical analysis of Boivin antigen indicated that the lipopolysaccharide and protein components were not complexed, but were co-extracted. the lipopolysaccharide (endotoxin) moiety was responsible for the antiviral activity and the endotoxin- associated proteins potentiated the antiviral effect.

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Document Details

Document Type
Technical Report
Publication Date
Dec 17, 1985
Accession Number
ADA162656

Entities

People

  • Alvin L. Winters
  • Gary L. Sloan
  • Paul A. Leblanc

Organizations

  • University of Alabama

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biological Sciences
  • Blood
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Gel Electrophoresis
  • Health Services
  • Infection
  • Lethal Dosage
  • Lipopolysaccharides
  • Lymphocytes
  • Microbiology
  • Military Research
  • Paper
  • Subcellular Fractions
  • Viruses

Fields of Study

  • Medicine

Readers

  • Analytical Chemistry
  • Parasitology and Pharmacology of Malaria.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech