The Effects of Ketamine on Rhesus Monkey Skeletal Dynamics.
Abstract
Four young male Rhesus monkeys were exposed to intramuscular injections of ketamine anesthetic (15 mg/kg) on eight selected days of a 28 day experiment. The subjects were dosed with bone labeling compounds to determine the effect ketamine had on bone modeling/remodeling dynamics. Trabecular bone sections of T sub 9 and L sub 4, and cortical bone sections of proximal femur and midshaft femur were used for histomorphometric analysis. Urine creatinine and calcium, and serum alkaline phosphatase and calcium levels were determined. Vertebral centrum compression tests were conducted on selected thoracic and lumbar levels. Stiffness, ultimate load and modulus showed significant increases in the ketamine exposure group. The results of the trabecular histomorphometry showed a possible increase in mineralization lag time or slower mineralization. Cortical bone histomorphometry could indicate activation of the skeletal system. The experimental results lead to the conclusion that something affected the mechanical strength parameters and the bone remodeling dynamics of the ketamine exposure group. It is unclear as to whether these differences are strictly due to ketamine as stress and age difference were other influencing factors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1985
- Accession Number
- ADA162848
Entities
People
- Clarence M. Oloff
- K. C. Smith
- Kristin N. Swenson
- Marvin E. Souder
Organizations
- Armstrong Laboratory