Effect of Adjuvants on Response to Pneumococcal Polysaccharide Injected Intraperitoneally. Platelet-Derived Immunoregulatory Activity

Abstract

Studies on the immunoaugmenting effect of a platelet-derived serum factor were extended to include 1) identification of the factor as the alpha- granule constituent known as platelet factor 4. The cells with affinity for this factor were identified as Ly2+, Ly22+, Qa1+, QA4+, Qa5+, Ly6+ and Ly1-, L3T4-, Thyl+ cells. Effects of PF4, detoxified endotoxin, IgD and 8-mercaptoguanosine on antibody production to pneumococcal polysaccharides types 3 and 14 were examined. Two aspects are being studied separately a) enhancement of the response (which is particularly good with endotoxin injected 4 days after antigen) and b) prevention of the tolerizing effect of slightly higher than optimal doses of polysaccharaide (which may be possible with the platelet factor).

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 15, 1985
Accession Number
ADA162996

Entities

People

  • G. J. Thorbecke
  • Zoltan Ovary

Organizations

  • NYU Langone Health

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Absorption
  • Antibodies
  • Availability
  • Bacteria
  • Blood
  • Blood Coagulation Factors
  • Cells
  • Classification
  • Endotoxins
  • Lymph Nodes
  • Lymphatic System
  • Lymphocytes
  • Materials
  • Military Research
  • Polysaccharides
  • Security
  • Survival

Fields of Study

  • Biology
  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Immunology
  • Instructional Design and Training Evaluation.