Studies on the Inhalation Toxicity of Dyes Present in Colored Smoke Munitions. Phase II Studies: Range Finding and Toxicokinetics Studies of Inhaled Dye Aerosols
Abstract
The USAMBRDL has an interest in the potential inhalation toxicity of yellow dye (SY) and a yellow/green dye mixture (SY/SG) used in colored smoke munitions. In the rangefinding studies, no mortalities or life-threatening lesions were observed in rats exposed for as long as 6 hours per day for 5 days to airborne concentrations greater than 1 g/cu m of either SY or SY/SG. The particle size of the aerosols employed was about 5 micrometers MMAD. In the toxico-kinetic studies, rats inhaled pure 14C-SY aerosols or 14 micrometers C-SY aerosols in combination with SG (a 0.6 ratio of yellow to green by weight). SY was rapidly cleared from the respiratory tract (T sub 1/2-approximately 3 hr.). SG, however, was retained for a longer time (T sub 1/2 > 22 days). The major pathway for excretion of SY metabolites was the feces, but some metabolites were also excreted in urine. There was no effect of SG on the kinetics of distribution and elimination of SY. The rapid absorption, distribution, and excretion of SY compared to SG may explain, in part, the differences in lowest toxic concentration observed in the Phase III toxicity studies conducted at ITRI (>250 mg/cu m for SY and > or = 50 mg/cu m for SG).
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 15, 1985
- Accession Number
- ADA163267
Entities
People
- D. E. Bice
- F. F. Hahn
- J. S. Dutcher
- Rogene F. Henderson
- T. C. Marshall
Organizations
- Lovelace Foundation