Comparison of the Effects of Soluble and Particulate Forms of Glucan, an Immunomodulator, on Prostaglandin Synthesis by Rat Peritoneal Macrophages

Abstract

GLUCAN, AN IMMUNOMODULATOR derived from the yeast Saccharomyces cervesiae, exists in two preparations, particulate (glu-P) and soluble (glu-F). Both preparations enhance host antibacterial and antineoplastic resistance. Unlike glu-F, glu-P is associated with granulomatous reactions within the reticuloendothelial system (RES) and endotoxin sensitivity. Since some of the adverse effects of glu-P may be mediated by prostaglandins (PGs), we compared the effects of glu-P and glu-F on PG production by rat peritoneal macrophages (PMos).

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1985
Accession Number
ADA164185

Entities

People

  • Erwin F. Hirsch
  • Gary J. Bowers
  • Mitchell P. Fink
  • Myra L. Patchen
  • Thomas J. Macvittie

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Analysis Of Variance
  • Azo Compounds
  • Cells
  • Infection
  • Macrophages
  • Materials
  • Metabolites
  • Monomolecular Films
  • Particulates
  • Prostaglandin
  • Reticuloendothelial System
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

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