Calcium Antagonist and Heat-Induced Hepatic Injury,
Abstract
Isolated perfused rat livers exposed to 42 C for 90 minutes produce membrand changes which appear to be similar to those induced by toxic chemicals or hypoxia. Three calcium antagonists (nifedipine, dantrolene, and verapamil) which have been reported to reduce irreversible cell injury were separately included in perfusates of moderately heated livers. Potassium and transaminase leakage, bile production and ultrastructure were used to compare heated livers perfused with and without Ca2+ antagonists. Neither of these Ca2+ antagonist improved the ultrastructure or function of the heated livers; however, dantrolene produced detailed vesicular endoplasmic reticulum while verapamil produced vesicular endoplasmic reticulum and unique ring-shaped mitochondria. These changes indicated selective intracellular action on membranes of heated liver cells without protective effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 02, 1986
- Accession Number
- ADA164347
Entities
People
- Charmaine Stevens
- Irwin Leav
- Michael Blaha
- Patricia Daum
- Wilbert Bowers Jr.
Organizations
- United States Army Research Institute of Environmental Medicine