Investigation of T-2 Mycotoxin-Induced Cytotoxicity in Vitro and Protective Effects of Flavonoid Compounds.

Abstract

Aspects of the in vitro cytotoxic effects of T-2 mycotoxin on murine thymocytes were investigated. Cytotoxicity was found to be consistent when tested bi-weekly for a four month period. Cytotoxicity reached maximal values over a narrow range of doses and was dependent on temperature (37 C optimum) and number of cells in the reaction mixtures. Quercetin, a flavonoid compound was able to decrease the effect of T-2 toxin when the drug was added within an hour of mixing the T-2 toxin with the thymocytes.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1986
Accession Number
ADA164573

Entities

People

  • A. R. Bhatti
  • D. Penman
  • N. P. Erhardt
  • R. J. F. Markham
  • V. L. Dininno

Organizations

  • Defence Research and Development Canada

Tags

Communities of Interest

  • Counter IED

DTIC Thesaurus Topics

  • Abstracts
  • Anti-Bacterial Agents
  • Blood
  • Blood Cells
  • Cell Membrane
  • Cells
  • Eukaryotes
  • Fungi
  • Granulocytes
  • Hemolysis
  • Inhibition
  • Lymphocytes
  • Thymocytes

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Mathematics or Statistics
  • Mycotoxin ecology in Amazonian ecosystems.