Acute Oral Toxicity (LD50) of Guanidine Hydrochloride in Rats

Abstract

Nitroguonidine is being evaluated by the US Army as a replacement for the nitrocellulose component of certain propellants/munitions. The acute oral toxicity of guanidine hydrochloride was determined in male and female Sprague-Dawley rats by using the oral gavage single-dose method. The LD50 + or - S.E. for male rats was 556.5 + or - 29.7 mg(base)/kg and 474.6 + or - 35.3 mg(base)/ kg for female rats. Clinical signs were observed in both the gastrointestinal (GI) tract and the central nervous system-neuromuscular junction (CNS-NM). Symptoms referable to the GI tract included increased salivation, hunched posture, and diarrhea. CNS-NM signs included disorientation, increased startle reflex, hyperactivity, jumping behavior, presence of tremors/twitching and depression of grasping and righting reflexes. These results place guanidine hydrochloride in slightly toxic and moderately toxic ranges respectively.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1985
Accession Number
ADA164654

Entities

People

  • Don W. Korte Jr.
  • Earl W. Morgan
  • Steven K. Sano

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Bioengineering
  • Biological Sciences
  • Biomedical Research
  • Body Weight
  • Central Nervous System
  • Digestive System Processes
  • Health
  • Lethal Dosage
  • Materials
  • Medical Personnel
  • Military Research
  • Nervous System
  • Peripheral Nervous System
  • Physicians
  • Plastic Explosives
  • Statistical Analysis
  • Triple Base Propellants

Readers

  • Toxicology/Environmental Toxicology