Reduced Serum T sub 4 and T sub 3 and Their Altered Serum Binding after Burn Injury in Rats
Abstract
In humans, a reduction in the circulating concentrations of bioactive thyroid hormones is characteristic of nonthyroidal illness (NTI). In burned patients, similar to patients with other NTI, serum concentrations of 3,5,3' - triiodothyronine (T3) and often tetraiodothyronine (T4), as well as the indices of free hormonal concentrations, FT3I and often FT4I (index = total hormone concentrations, FT3I and often FT4I(index = total hormone concentration times T3 uptake), are suppressed. To investigate the significance of such changes, we have characterized serum T4 and T3 after full-thickness scald burns (60% body surface under anesthesia) of 270-gm male Sprague-Dawley rats housed in a light:dark cycle of 14:10 hr. Because of failure of the in vitro charcoal T3 uptake to account for this serum bindng abnormality, the results are most consistent with a burn-induced circulating inhibitor(s) for binding of T4 and T3, not only to transport proteins but also in vitro charcoal, perhaps similar to inhibitors previously described in the sera of patients with various nonthyroidal illnesses. The thermally traumatized rat appears to be a good model for thyroid changes in burns and other nonthyroidal illness.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1985
- Accession Number
- ADA164823
Entities
People
- Arthur D. Mason Jr.
- Basil A. Pruitt Jr.
- George M. Vaughan
- Khan Z. Shirani
Organizations
- United States Army Institute of Surgical Research