Urinary and Hematological Indices of Hypohydration,
Abstract
As part of a large scale field feeding system test we had the unique opportunity to collect and study hundreds of overnight urine aliquots which were obtained immediately prior to a fasting blood sample on days 1, 20, and 44 of the field test. To evaluate the hydrational status of test subjects and criteria of hypohydration, urine aliquots were categorized by specific gravity > or = 1.03 (n=124) or < 1.03 (n=540). Creatinine levels were elevated (p<.001) in the concentrated urine samples, but a decreased trend in Na(+)/K(+) ratios in these samples failed to achieve statistical significance (p=0.1). However, when individuals with high specific gravity urine were further subclassified by a criterion of weight loss > 3% from original body weight, then creatinine concentrations were elevated (p=.05) while Na(+)/K(+) ratios were decreased (p=.05) when compared with levels in subjects also with high specific gravity but weight loss < 3%. Serum urea nitrogen/creatinine ratios were significantly increased (days 1 and 44, p=.02) in test subjects whose urine samples exceeded 1.03 in specific gravity. The results of this study indicated that prodromal hypohydration, indicated by concomitant elevations in urinary specific gravity and creatinine, was not reflected in the common indices of circulatory hypohydration- hematocrit and osmolality. Alternatively, urea nitrogen/creatinine ratio may be a sensitive circulatory index of imminent hypohydration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1986
- Accession Number
- ADA165015
Entities
People
- D. Carlson
- D. Schnakenberg
- P. C. Szlyk
- R. P. Francesconi
- R. W. Hubbard
Organizations
- United States Army Research Institute of Environmental Medicine