Dermal, Eye, and Oral Toxicological Evaluations.
Abstract
All five of the powdered test samples (11357-8,9,12,13,14)* were evaluated for dermal and eye irritation and oral toxicity. Dermal Irritation scores ranged from 0 to 0.08 with sample 11357-12 causing no irritation. Eye irritation ranged from non-irritating (11357-8) to moderately irritating (11357-13). When screened for oral toxicity, samples 11357-8,9, and 12 had oral LD50 values of greater than 5000 mg/kg, and samples 11357-13 and 14 had combined (male and female) LD50 values of greater than 3300 mg/kg. The three materials tested for dermal toxicity (11357-8,9,12) had LD50 values of greater than 2000 mg/kg body weight. Further testing of sample 11357-9 in the Two Week Multiple Dose Dermal Toxicity Study using dose levels of 1000, 200 and 50 mg/kg revealed no definitive increase in severity of skin lesions with increasing dose levels. It was also determined that sample 11357-9 was not a dermal sensitizer. Keywords: Rabbit, Rat, CI Solvent Green 3/CI Solvent Yellow 33, CI Solvent Yellow 33, Copper-Zinc Coated Powder, Copper-Zinc Powder, 1-acetyl-3,5,7-trinitro-1,3,5,7-octahydrotetrazocine (SEX).
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1985
- Accession Number
- ADA165408
Entities
People
- Elliot B. Gordon
- Indu A. Muni
- Jane B. Goodband