Synthesis of Amino Derivatives of Dithio Acids as Potential Radiation Protective Agents
Abstract
Dithio acids should be more effective agents for hydrogen atom transfer to effect repair of radiation-damaged DNA or other cellular substance than thiols since the pH for maximum rate of transfer for dithio acids (pH 4-6) is closer to cellular pH for maximum rate of H transfer from thiols (pH 10-11). The synthesis of several N-methylquinolinium-2-dithioacetic acid derivatives has been accomplished, and the compounds were submitted for radiation-protective screening. These included the zwitterion of the dithio acid, the bis (methylthio) derivative, and the methyl-thio N-morpholino and methylthio N- piperidino derivatives. Two of the compounds had 6-methyl substituents. Various attempts to prepare aliphatic amino dithio acid esters were made, including the reaction of an imino thio ester with H2s, the reaction of an aledhyde with morpholine and sulfur, and the reaction of a protected thiol ester with Lawesson's reagent. None of these procedures gave pure, identifiable products. Keywords: Copper complex of bis(methylthio) compound.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1983
- Accession Number
- ADA165798
Entities
People
- William O. Foye