Evaluation of Chloropentafluorobenzene in a Battery of in vitro Short Term Assays
Abstract
A fully substituted halogenated benzene, chloropentafluorobenzene, was evaluated in a battery of in vitro short-term bioassays to assess its potential biological activity. The assays conducted were Ames Salmonella/ mammalian microsomal mutagenicity assay, the CHO gene mutation assay, the CHO/ sister chromatid exchange and chromosome aberrations assay, a DNA repair assay utilizing primary rat hepatocytes and the BALB/c-3T3 cell transformation assay. The test compound, although a liquid, precipitated out of solution in solvents compatible with the bioassays. Therefore, the actual soluble concentrations in the test medium were not known. Under these conditions, chloropentafluorobenzene produced a positive response in the CHO/chromosome aberrations assay and in the primary rat hepatocyte/DNA repair assay but was not active in the remaining four in vitro assays.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1986
- Accession Number
- ADA165849
Entities
People
- Alice S. Tu
- Andrew Sivak
- Mildred G. Broome
Organizations
- Arthur D. Little