Teratological Assessment of Trinitro-RDX in Rats.

Abstract

A teratology study in rats was performed to define the effects of trinitro - RDX on the developing fetus, oral dosage levels of 2, 6 and 20 mg rat/kg/day were administered to pregnant female rats critical period of organogenesis. Fetuses derived from RDX - treated dams had significantly lower body weights and lengths when compared to control fetuses. It was recommended that human females of childbearing age be protected from exposure to trinitro - RDX by means of appropriate industrial hygiene practices. It was further recommended that additional development toxicity studies be performed. Keywords: Fetotoxicity.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1986
Accession Number
ADA166249

Entities

Organizations

  • United States Army Medical Command

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Death
  • Environmental Health
  • Environmental Protection
  • Experimental Data
  • Fertility
  • Health
  • Hygiene
  • Implantation
  • Industrial Hygiene
  • Liquid Chromatography
  • Materials
  • Pilot Studies
  • Rdx
  • Soft Tissues
  • Standards
  • United States

Readers

  • Agricultural Chemistry/Soil Science
  • Toxicology/Environmental Toxicology