The Screening and Evaluation of Experimental Antiparasitic Drugs.
Abstract
The investigations undertaken during this report period included three antimalarial screens, two african trypanosome screens, and an american trypanosome screen. The three antimalarial screens were; a primary blood schizonticidal test using Plasmodium berghel, a primary causal prophylactic tests using Plasmodium yoelii and Anopheles stepheni mosquitoes, and a secondary drug screening system using both of the above species of rodent malaria. The two African trypanosome sysems included a primary screen and a secondary drug-resistant screen. The America trypanosome system was a primary test. The primary test in African trypanosomiasis evaluated compounds for trypanosomicidal activity against a drug-sensitive line. 2069 three dose-level tests were performed with 82 compounds exhibiting activity. In the drug-resistant screen 10 compounds wre tested for activity against one or more resistant lines. A special test was done to see how long resistance lasted in the pentamidine, melarsoprol, and suramin-resistant lines. In the primary test in American trypanosomiasis 126 dose-level tests were performed. Three compounds were found to be active.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1983
- Accession Number
- ADA166296
Entities
People
- Arba L. Ager Jr.
Organizations
- University of Miami