Primary Eye Irritation of Guanidine Nitrate in Male Rabbits.

Abstract

The primary eye irritation potential of guandine nitrate was determined in male New Zealand White rabbits by using a modified Draize method. The compound produced a positive test reponse as it caused mild-to-moderate irritation. Signs of irritation were erythema and chemosis of the conjunctiva, iritis, and corneal lesions. All 6 animals tested showed one or more of these lesions. Potential corrosive properties of guanidine nitrate were indicated by observation of pannus (1 of 6) and corneal erosions (2 of 6) that persisted through termination at day 21. Keywords: Toxicology.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1986
Accession Number
ADA166449

Entities

People

  • Don W. Korte Jr.
  • Earl W. Morgan
  • Joy W. Bauserman

Organizations

  • Letterman Army Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animal Structures
  • Bioengineering
  • Biological Sciences
  • Biomedical Research
  • Engineering
  • Governments
  • Guanidine Nitrates
  • Health
  • Laboratory Animals
  • Materials
  • Materials Laboratories
  • New Zealand
  • Plastic Explosives
  • Toxicology
  • Triple Base Propellants
  • United States

Readers

  • Rocket Propulsion.
  • Toxicology/Environmental Toxicology