Safety and Immunogenicity Testing of a Pilot Polysaccharide Vaccine Preparation to Pseudomonas aeruginosa.

Abstract

We prepared and tested a high-molecule weight polysaccharide antigen from three different immunotype strains of Pseudomonas aeruginosa. These materials were tested in humans for safety and immunogenicity. All three vaccines were found to be safe in doses between 100-250 mcg. They were also found to be immunogenic, inducing antibody responses in 40-90% of immunized persons. These antibodies were also found to be functional in their ability to kill the bacterim in conjunction with white blood cells. In addition, we showed that these vaccines were able to induce and effect on T-cells of immunized animals and humans. This T-cell response may be an important component of the overall immune response to these antigens that results in protective immunity.

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Document Details

Document Type
Technical Report
Publication Date
Feb 15, 1985
Accession Number
ADA166685

Entities

People

  • Gerald B. Pier

Organizations

  • Brigham and Women's Hospital

Tags

DTIC Thesaurus Topics

  • Antigens
  • Biomedical And Dental Materials
  • Blood
  • Burns
  • Cells
  • Chemistry
  • Health Services
  • Immune Serums
  • Leukocytes
  • Lymphocytes
  • Medical Personnel
  • Microbiology
  • Polymeric Films
  • Vaccines

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech