Topical Hazard Evaluation Program of Candidate Insect Repellents AI3-35768e and f, AI3-70948Ga, AI3-39007a, AI3-38323b, AI3-38324b, AI3-38326b, AI3-38304b, AI3-38321b, AI3-37487b.
Abstract
Lots e and f of AI3-35768 caused severe primary irritation and necrosis (AI3-35768f) of the intact and abraded skin of rabbits. When applied as a diluted ethanol solution AI3-35768e caused mild primary skin irritation. AI3-70948Ga and AI3-39007a caused no primary skin irritation but caused moderate to severe eye irritation. Chemical AI3-70948Ga was only slightly toxic to rats by the oral route (ALD 5000mg/KG) and was not a sensitizer within the limits of our test. AI3-38323b produced moderate primary skin irritation. Chemicals AI3-38324b, AI3-38326b, AI3-38304b, and AI3-38321b produced moderate to severe eye irritation with lesions which persisted at 7 days post application. AI3-38304 and AI3-38321b produced mild primary skin irritation while AI3-37487b produced severe primary skin irritation, necrosis, and eschar formation. These chemical are not recommended for further entomological testing, however, if efficacy data should warrant, such chemicals could be resubmitted in a further purified form or at the intended use concentration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1986
- Accession Number
- ADA166987
Entities
People
- R. D. Russell
Organizations
- United States Army Medical Command