Modification of WR 2721 of Acute and Chronic Effects of Radiation Injury to the Lung.
Abstract
The purpose of the work was to study the effect of WR2721, without without corticosteroids, on acute and chronic lung injury caused by a sublethal dose of ionizing radiation. The model used was that of 3000 rads unilateral radiation to the left lung of adult rats. The degree of injury and the amount of protection were to be assessed at 12 weeks, 26 weeks and 52 weeks post radiation by quantitative ultrastructural examination and physiological measurements. To date, we have completed full ultrastructural morphometry on about half the animals scheduled to be studied at 12 weeks post-radiation. At this early time point, WR2721 alone does not seem to confer significant protection. However, WR2721 plus corticosteroids seemed to decrease the amount of radiation injury as evidenced by the following when compared to the group receiving radiation alone: less volume of cellular and non-cellular interstitium, less number of alveolar macrophages and interstitial cells, lesser mean thickness of the interstitium, and increased volume of intra-capillary blood. We conclude that WR2721 and corticosteroids have the combined effect of reducing lung injury present 12 weeks after a single dose of 3000 rads. The effects of WR2721 along were not noticeable at this early time point, but might perhaps be significant at later time points.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 31, 1983
- Accession Number
- ADA167390
Entities
People
- Lyn A. Thet
Organizations
- Duke University